This is Part 5 of our GLP-1 series for India, and it focuses only on GLP-1 side effects, the real risks, and smart ways to stay safe as an Indian patient
Funding No funding was used for this research
When taken orally, semaglutide works by several complementary mechanisms: Enhances insulin release only when blood glucose is elevated Suppresses the release of glucagon, a hormone that raises blood sugar Slows stomach emptying, helping you feel fuller for longer May reduce appetite and caloric intake, underpinning its weight loss benefit This targeted approach helps reduce HbA1c and fasting plasma glucose, while also supporting significant, sustained weight loss in eligible patients
Therefore, you accumulate fat
Retatrutide Retatrutide represents another approach to multi-pathway activation, functioning as a triple agonist (GIP/GLP-1/glucagon) in a single molecule: Cagrilintide + GLP-1 Approach: Two separate injections Amylin + GLP-1 pathways Established safety profile for each component Flexible dose adjustment of each component Retatrutide Approach: Single injection GIP + GLP-1 + Glucagon pathways Novel triple mechanism in one molecule Fixed ratio of pathway activation Both approaches show promise for significant metabolic benefits, though they achieve multi-pathway activation through different strategies
