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Briefly, NQO1 catalyzes the reduction of menadione to menadiol which in turn reduces MTT to its water-soluble formazan

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Small decreases are noted between ages 30 and 50, and decreases accelerate after the fifth decade of life, with some people experiencing as much as a 15 percent strength loss per decade, with more than 50 percent of fast twitch muscle fibers being lost by 75 years of age