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Further investigations are needed to clear the data in the literature completely

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A putative biological pathway affected by a panel of eight HFpEF-related miRNAs (hsa-miR-193a-5p, hsa-miR-30a-5p, hsa-miR-106a-5p, hsa-miR-191-5p, hsa-miR-486-5p, hsa-miR-181a-2-3p, hsa-miR-660-5p and hsa-miR-199b-5p) has been reported as valuable in identifying HFpEF.158 However, there is no consensus on the choice of specific circulating miRNAs that might better serve as HFpEF biomarkers

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