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Vit-E could effectively prevent ferroptosis by reducing the Fe 3+ center to inactive Fe 2+ in lipoxygenase (LOX), thereby inhibit enzyme activity of LOX

stem cell activation (PMID: 20880960) Hair: Stimulated hair follicle stem cells in preclinical research (PMID: 14657002) Human Clinical Data Both peptides lack robust human clinical trial data, though Thymosin Beta-4 (the parent compound of TB-500) has more formal clinical exposure through RegeneRx Biopharmaceuticals' development programs

Acknowledgements This work was supported by grants from the National Natural Science Foundation of China (82103369) and the China Postdoctoral Science Foundation (2022M710757)