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Weight of evidence: Overall evidence is Low : primarily preclinical with heterogeneous designs and no consistent human biomarkers

Increased functional connectivity could be inferred from the augmented spinogenesis, the colocalization of synaptic markers on the newly formed dendritic spines, and a concomitant enhancement of miniature excitatory postsynaptic currents

Melatonin exerts protective effects in an ILC2-biased model of allergic airways disease, even in the presence of canonical receptor blockade To determine whether the protective effects of melatonin extended beyond allergen-driven disease, we next employed an ILC2-biased IL-33 model of allergic airways inflammation ( Figure 2A )