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One alternative pharmacotherapy has been to administer inosine, a purine that is converted in the body to UA

These symptoms indicate the body's reduced capacity to manage toxins and oxidative stress.

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Category 2 substances have been identified as presenting potential safety risks

Under cellular stress, Nrf2 dissociates from Keap1, becomes activated, translocates to the nucleus, and initiates the expression of numerous cytoprotective genes, increasing cell survival capacity (Kensler et al., 2007)