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The decision should be made collaboratively between patient and clinician, considering efficacy, safety, administration route, cost, and individual treatment goals, in line with NICE NG28 guidance

Lifestyle Modification There is limited knowledge on the effectiveness of diet and exercise in the management of metabolic disturbances in patients with lipodystrophy

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Coskun 2022 mmc3 Table 3 + mmc1 Table S8 Phase 1 single-ascending-dose study (NCT03841630, n=45, conducted in Singapore)

Staying hydrated and avoiding carbonated drinks during this adjustment window can significantly reduce symptom intensity