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The balance of cellular SUMOylation is determined by the restrictive SUMO precursors and mature SUMO isoforms, as well as the SENP family[95]

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Further DBPC studies using biomarkers of metabolic pathways related to BH 4 metabolism will be needed to determine which children with ASD will most benefit from formulations of BH 4 supplementation like sapropterin

Also, miR-NPs showed a significant reduction in expression of P-P65 and MEKK3 protein kinase