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In an exploration of the metabolites and metabolomics of Lonicera japonica to uncover the pivotal antipyretic active compounds and their modes of action, it was determined that mitogen-activated protein kinase (MAPK) 3 and protein kinase B (AKT) 1 are the key targets chiefly modulated by chlorogenic acid (CA) and swertiamarin (SWE)

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Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis

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In support of these findings are the results from a systematic review that focused on studies conducted in India, where the prevalence of vitamin B 12 deficiency among pregnant women is up to 70 % and is considered one of the highest in the world (Reference Behere, Deshmukh and Otiv125)