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Leffler DA, Kelly CP, Green PHR et al (2015) Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial

Primary outcome of ACR 20 response rate at week 12 were as follows: 37% for brodalumab 140mg (p=0.03), 39% for brodalumab 280mg (p=0.02), and 18% for placebo

ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes

So it's really changing the way cells behave at that level

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