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Common Causes of Injection Reactions Histamine release from immune cells in the skin Sensitivity to specific peptide structures Minor tissue trauma from the injection Injection volume or concentration Irritation from bacteriostatic water Why Some People React More Than Others Individuals with more reactive immune systems may experience stronger responses

From there, how peptides work explains the mechanisms behind these molecules

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Nausea, diarrhea, vomiting, constipation, abdominal discomfort, indigestion, bloating, and reflux appear prominently in current prescribing information for semaglutide and tirzepatide