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Pawlak and others reviewed studies of B12 deficiency among vegetarians and vegans using serum B12 (Pawlak, 2014) as well as methylmalonic acid and holotranscobalamin (Pawlak, 2013)

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The addition of GIP receptor activation in Retatrutide appears to improve tolerability rather than worsen it, which is consistent with what was observed in the shift from Semaglutide to Tirzepatide