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However, people always concentrate their mind on the efficacy and the mechanism of permeation of the conjugates across BBB, but overlook the toxicity of the membrane-permeable peptide itself. Once we injected intravenously not very large amounts of gamma-aminobutyric acid-MPP (GABA-MPP) to the mice, to our great surprise, the mice died within seconds with seizure, whereas the GABA control mice well survived
523 Together, these studies support HSP90 inhibition as a viable upstream strategy to dampen pathogenic immune activation
2019 May 16;2(3):e00068
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