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FcRn is found in both hematopoietic and non-hematopoietic cells, including endothelial and epithelial cells as well as monocytes, macrophages, neutrophils, B cells, and dendritic cells

Current evidence has not confirmed a direct causal relationship in most reported cases

While the immune system reacts abnormally to progesterone, many symptoms are driven by mast cell activation and histamine release rather than classic autoantibodies, which is why antihistamines are often effective

Many are accomplished, career-focused women who have raised families and are now investing in themselves

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