whats the difference between semiglutide and tirzepatide vs. Ozempic: Comparing Diabetes Treatments & Weight Loss Benefits What Are the Side Effects

The anti-obesogenic effect of GLP-1RAs is mediated by direct inhibition of the feeding center and indirectly through modulation of energy expenditure (Jepsen and Christensen 2021)

doi: 10.1016/j.toxicon.2018.09.004 Gartia, Janeka, Barnwal, Ravi Pratap, Anangi, Raveendra, Giri, Ashok R., King, Glenn and Chary, Kandala V

That story seemed intuitively obvious, and the STEP 9 trial published in NEJM supported it 407 obese patients with knee OA experienced significant pain reduction and improved function with semaglutide 2.4 mg weekly versus placebo

However, several important safety considerations warrant attention

Li L, Zhao S, Leng Z et al (2024a) Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head