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Phentermine is indicated for short-term use (a few weeks) for patients with an initial BMI* of 30 or more (obese) or 27 or more (overweight) with at least one weight-related condition such as controlled high blood pressure, diabetes, or high cholesterol and should be used in combination with regular exercise and a reduced-calorie diet

The genetic variants that shape baseline GLP-1, appetite, and energy-balance biology stay the same regardless of which program writes the prescription, which is why upstream testing applies across every alternative

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95% CI, 16.2 to 13.4