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(2) Gastric emptying delaypramlintide slows gastric emptying by 2030%, spreading glucose absorption over a longer period and flattening the postprandial glucose curve

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The compound is highly specific for GLP-1R, as it is unable to activate the closely related human receptors for glucagon, glucagon-like peptide-2 (GLP-2) and secretin

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The SELECT trial, published in the New England Journal of Medicine , found that semaglutide, known by the brand name Ozempic, significantly reduced the risk of heart attacks and strokes in people with obesity and established cardiovascular disease