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These usually occur during the dose-escalation phase and tend to diminish over time. Patients can improve tolerability by consuming smaller portions and avoiding high-fat or spicy meals. Dosing should start low and be increased gradually based on tolerance and clinical goals. Administration and Storage Considerations Injectable agents such as dulaglutide and semaglutide must be refrigerated before the first use

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Genetic influences Once absorbed, glucosinolate-derived isothiocyanates (like sulforaphane) are promptly conjugated to glutathione by a class of phase II detoxification enzymes known as glutathione S -transferases (GSTs) ( Figure 3 )

[15] Lu, S.C