Carabotti M, Scirocco A, Maselli MA, Severi C
meningitidis activates both canonical and non-canonical pathways in the host, with predominance of the alternative caspase-3 mediated-GSDME activation in vitro in different cell lines (Tal et al., 2022) and of the GSDMD-dependent pathway in vivo in an intracisternal infected mouse model of meningitis (Pagliuca et al., 2024)
In summary, monitor the injection site (if pain increases or the area gets very red, hot, and swollen, inform your doctor as that could indicate injection-site infection, which is exceedingly rare with proper technique)
Coming off Category 2 is not FDA approval, and the PCAC review concerns pharmacy compounding, not research-grade material
doi:10.1016/j.ebiom.2025.105836 Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use.