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A 2025 systematic review in orthopaedic sports medicine likewise found that the clinical evidence was extremely limited

[5] Brcic, L., Kolenc, D., Blagaic, A.B., & Sikiric, P

Adsorption of DNA and aptamers to sodium urate crystals and inhibition of crystal growth

This work was supported by the Wilmot Cancer Institute Predoctoral Fellowship (G.A.), Wilmot Cancer Institute Pilot Funding (I.S.H.), the American Association for Cancer Research and Breast Cancer Research Foundation (20-20-26-HARR) (I.S.H.), Breast Cancer Coalition of Rochester (I.S.H.), a Sir Henry Wellcome Postdoctoral Fellowship (M.E.K.), and a FNR-CORE grant C21/BM/15796788 (D.B.), and NIH grants R01CA269813 (I.S.H.), R37CA230042 (G.M.D), R24AA022057 (V.V.), R01AA028859 (Y.C.), AI150698 (J.M.), K01CA240533-01A1 (C.L.C.), and R01AR078000 (R.T.D.)

For gastrointestinal applications, oral administration is also studied, with the same dose range delivered in capsule form