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Following DE induction, the cells underwent hepatic specification to produce hepatoblasts (HBs)

When the solution freezes, ice crystals form that physically shear peptide molecules apart

In addition to inducing fatty liver, HFD also promotes systemic metabolic syndrome with insulin resistance and glucose intolerance

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Focusing on dynamic associations between metabolism and disease stages, longitudinal metabolomic cohort studies can track changes in metabolic profiles of patients from early asymptomatic stages to stable and acute exacerbation phasesidentifying core metabolic characteristics at different disease stages and addressing gaps in the current understanding of correlations between disease staging and metabolic abnormalities