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Their findings suggest a potential risk of NAION associated with prescriptions for semaglutide , although additional prospective studies are needed to prove causality

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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

The votes were nonbinding, and final FDA action remained pending as of July 26, 2026