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Similarly, a 2024 study published in the Journal of the American Medical Association analyzed data from 16,827 patients and found that those prescribed semaglutide had a significantly higher risk of developing NAION compared to those on non-GLP-1 medications

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Furthermore, ongoing innovations in these therapies hold promise for expanded clinical applications and improved health outcomes

Hyperglycemia and lipotoxicity drive sustained ROS production through NADPH oxidase (NOX4), mitochondrial respiratory chain complexes I and III, and xanthine oxidase, while concurrently depleting antioxidant defenses such as glutathione (GSH), superoxide dismutase (SOD2), and catalase

Yaribeygi et al., 2019