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The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance

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Although these assays were conducted in aqueous solution and must be interpreted with caution, as the protein environment can further modulate the redox potential of flavins, this combined evidence supports a mechanism in which roseoflavin-derived metabolites incorporate into FSP1 but cannot accept electrons from NAD(P)H, thereby inactivating the enzyme