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Semaglutide, manufactured by Novo Nordisk under the brand names Ozempic, Wegovy, and Rybelsus, is FDA-approved for type 2 diabetes and obesity patients

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body composition (the ratio of fat to lean mass)

In the STEP 1 trial, adults with overweight or obesity who used once-weekly semaglutide 2.4 mg plus lifestyle intervention lost an average of 14.9% of baseline body weight by week 68 , compared with 2.4% in the placebo group

Mechanistically, GSH depletion does not cause global protein oxidation but instead selectively oxidizes and destabilizes fatty acid synthase while decreasing lipogenic gene expression at the transcriptional level, collectively suppressing lipogenesis