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In the SWOG S0221 trial and related analyses, the use of antioxidant supplements during chemotherapy was associated with potential trends toward worse clinical outcomes, including reduced disease-free and overall survival in exploratory analyses (348)

Whereas dietary supplementation of arginine significantly reduces MDSC frequency and ROS levels, restoring immune function and suppressing tumor progression [246]

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We also did not measure brain levels of glutamate or inhibitory GABA, which are neuro-transmitters known to be impacted by the ketogenic diet in various animal models

PMID: 12750433