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Primary endpoint: composite MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke)

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A Personalized, Physician-Guided Approach This is not a one-size-fits-all solution, so a comprehensive medical evaluation is essential to ensure a safe and effective treatment plan

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The ultimate pathways whereby these molecular changes may translate into changes in body weight and metabolic (dys)function are yet to be fully disclosed, but alterations in the hypothalamic proteome involved in inflammatory and apoptotic processes, as well as in autophagy and vesicular trafficking, may play a role