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Published rodent protocols typically use subcutaneous or intraperitoneal injection in saline vehicle, dosed in pulsed courses (for example 1 g/kg daily for 10 days, repeated quarterly)

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Neurotransmitters have either excitatory or inhibitory effects

Wang Z, Gurlo T, Matveyenko AV, Elashoff D, Wang P, Rosenberger M, et al

Tackling a challenging yet achievable weight and adapting to the new, higher intensity is muscle tension