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Using it correctly is the other half

The second study found that systemic exenatide or the DPP4 inhibitor sitagliptin decreased intravenous nicotine selfadministration in mice and that GLP1 receptor knockout mice, that is, mice lacking GLP1 receptors, selfadministered more nicotine than the wildtype controls (Tuesta et al., 2017)

Moreover, due to its high-throughput nature this assay can be readily applied to drug discovery screens, but we would also recommend testing promising drug candidates using the triolein-based method to recapitulate key findings