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Preclinical studies have identified many TCM formulations with therapeutic efficacy against AP, including Chaiqin chengqi decoction , Dahuangfuzi decoction , Chengqi-series decoction , Qingyi decoction , Qingxiajieyi formula , Dachengqi decoction , Dachaihu decoction , and Chaiqinchengqi decoction ( Dachengqi decoction ( Yinchenhao decoction ( Chaiqin Chengqi decoction ( Chaiqin chengqi decoction diminished pancreatic acinar cell necrosis and systemic inflammation by inhibiting the TLR4/NLRP3 pathway ( Qingyi decoction and its active ingredients (e.g., Wogonoside) alleviated pancreatic injury and systemic inflammation in AP by inactivation of the NF-B/NLRP3/Caspase-1 pathway ( Rhizoma Alismatis decoction alleviated AP by restoration of autophagy flux and mitochondrial homeostasis, leading to downregulation of NLRP3 and IL-1 in the pancreas
Pons R, Andreu AL, Checcarelli N, et al
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