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SGLT2 vs Dual Agonists: Putting Weight Loss in Context SGLT2 inhibitors like empagliflozin (Jardiance) offer modest weight reduction of approximately 4 to 6 pounds, a fraction of what dual agonists deliver

For people without diabetes who need a weight-loss medicine, Wegovy (semaglutide 2.4 mg) is the FDA-approved option and has shown an average weight loss around 15% of body weight in clinical trials when combined with lifestyle changes

Liraglutide, though, has been in shortage since April 2023, so the compounders are free to keep making it

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Going from 2.4 mg back to 1.7 mg, for instance, often provides significant side effect relief while maintaining most of the weight loss benefit