CysteineGSH axis in fibrosis control GSH, a key intracellular antioxidant, is synthesized from glutamate, cysteine, and glycine, with glutamatecysteine ligase (GCL) catalyzing the rate-limiting step[119]
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The nature of how impaired glutamate cysteine ligase, the enzyme that naturally produces gamma-glutamylcysteine (GGC), can make cells more susceptible to mutagens due to lower glutathione (GSH) [4, 5] has been well studied
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