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Fentanyl also elicited a marked and sustained (at least 60 min) decrease in Vt (coupled to the decrease in fr resulting in a marked decrease in Ve), inspiratory drive (Vt/Ti), PIF and PEF

Additionally, their small size, rapid reproduction cycle, and compatibility with high-throughput screening techniques provide unmatched efficiency in large-scale drug discovery studies (Koehler D, 2018)

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The theoretical concern: Any compound that stimulates cell proliferation, angiogenesis, and gene expression modulation raises oncological questions