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In addition, intestinal microbiota can isolate selenium and limit the availability of the host [129]

Most patients notice reduced appetite within the first week, with measurable weight loss visible within four to six weeks at therapeutic doses

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However, their physiological effects including delayed gastric emptying, reduced appetite, lower caloric intake and gastrointestinal side effects may indirectly influence nutritional status over time, particularly in individuals consuming substantially reduced food volumes

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