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Through dual GLP-1 and GIP receptor activation, tirzepatide targets metabolic dysfunction while influencing anatomical and inflammatory factors associated with upper airway collapse (17, 18)

Literature Search Strategy A structured literature search was performed across PubMed/MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant publications addressing body composition changes during GLP-1 receptor agonist therapy, the effects of testosterone and TRT on lean mass and skeletal muscle, and the intersection between metabolic weight loss and androgen physiology

Martuscello RT, Vedam-Mai V, McCarthy DJ, Schmoll ME, Jundi MA, Louviere CD, Griffith BG, Skinner CL, Suslov O, Deleyrolle LP, Reynolds BA (2016) A supplemented high-fat low-carbohydrate diet for the treatment of glioblastoma

A recent survey of social media users perceptions of GLP-1 inhibitors found that out of 12,136 Reddit comments, 14,515 YouTube videos, and 17,059 TikTok videos about GLP-1 medications (including Ozempic), 5% included the word insomnia. This does not qualify as a rigorously randomized controlled trial (RCT), emphasizes Jodie Pepin, Pharm.D., clinical pharmacy program director at Harbor Health

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