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SAFETY: Before use, perform a SPOT TEST to test for sensitivity as follows: Lather the soap up and apply to the intended area of use for up to one 30 seconds

115 , 117 , 118 , 119 Outcomes following longterm exposure of setmelanotide were assessed in 2 patients with POMC deficiency who participated in a Phase 2, openlabel pilot study, followed by an openlabel extension study, with each receiving setmelanotide daily for a range of 6.87.2 years

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For others, the benefits come with digestive side effects that are hard to ignore

Biophys Rev 13(2):259272