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Emerging evidence suggests that glucose metabolic regulation plays a pivotal role in modulating the TME by alleviating extracellular acidification and improving immune cell function, thereby overcoming immune tolerance and enhancing the therapeutic outcomes of immunotherapy [132]

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This dose should be maintained for at least four weeks to assess tolerance and initial therapeutic response before considering further dose escalation

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The main difference is not receptor target, but duration: DAC produces longer GH/IGF-1 signaling, while No DAC produces shorter GHRH-like signaling