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The primary objective of this substudy was to assess mean relative change from baseline in liver fat (LF) at 24 weeks in participants from that study with metabolic dysfunction-associated steatotic liver disease and 10% of LF

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Phase 2 dose-ranging trials followed in 20042006, and the pivotal Phase 3 trials (studies LIPO-010-05 and LIPO-010-06) ran from 2006 to 2009 , forming the efficacy basis for the November 2010 FDA approval