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A recent multicenter phase II study in biopsy-proven NASH patients demonstrated that semaglutide had significantly higher efficacy for NASH resolution than placebo

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Correspondingly, the inhibition of NF-B by BAY 11-7082 significantly increased the survived SGN numbers, while decreased the C-CASP3 positive SGN numbers and the C-CASP3 expression in peroxynitrite + BAY 11-7082 group compared with the peroxynitrite group (Figures 9DF)

50,51 DDIs with Narrow Therapeutic Index Drugs Other clinical studies on DDIs have investigated the delayed gastric emptying effect of GLP-1 RA on the pharmacokinetics of drugs with narrow therapeutic index (Table 5)

Acknowledgments The authors would like to convey thanks and express gratitude to all the partner universities and University of Debrecen for collaborating on this project