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Contacting Your Provider Most semaglutide-related leg cramps resolve within days to weeks with home management strategies: increase water intake to 100 ounces per day, stretch your calves and hamstrings for 30 seconds before bed and after waking, apply heat to cramped areas for 15 minutes, and eat potassium-rich foods or take a magnesium glycinate supplement (200400 mg daily, approved by your doctor)