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Currently, several therapies are emerging and undergoing trials in animal models

Despite not fully comprehending the mechanisms underlying these disorders in chronic kidney disease (CKD), the robust association among homocysteine, cysteine, S-adenosylmethionine, S-adenosylhomocysteine, and plasma creatinine levels, as well as the glomerular filtration rate (GFR), indicated that these compounds were excreted in the urine

Diabetologia 43:14351438 Herold S, Fago A (2005) Reactions of peroxynitrite with globin proteins and their possible physiological role