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Meal-stimulated plasma GLP-1 levels in response to a liquid meal test (187.5 ml, 450 kcal, 17.5 g fat, 54.0 g carbohydrate, 19.1 g protein, Abbott Ensure) were measured at baseline, fasted (0 min = T0) and 30 min after starting the liquid meal (T30)

This higher dosing specifically calibrated for weight management may explain why some patients experience more significant weight loss with Wegovy

However, there is an important detail people should understand: There have not yet been large direct head-to-head trials comparing retatrutide and tirzepatide under identical conditions

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