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Interestingly, several studies showed that cytokines and stress stimuli such as TNF-, interleukins, FAS ligand, heat shock, UV irradiation and also stressors that deplete glutathione such as ROS and 4HNE can activate sphingomyelinase, which leads to increased ceramide production 58,59,60

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Alcohol Consumption: The liver uses a massive amount of glutathione to process alcohol

The Master Switch: It rapidly activates a gene called Egr-1, which acts as a master controller to start building the proteins and vessels needed to close a wound