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10.4103/0378-6323.179088 Juhasz ML, Levin MK: The role of systemic treatments for skin lightening

Oral estrogen tablets : These are widely available and affordable

Patients should understand that diagnostic uncertainty does not prevent appropriate treatment and that treatment response can provide additional diagnostic confirmation

Several experimental studies showed that selenium reduces endothelial dysfunction and has a cytoprotective role [96], through SELENOS [97, 98] and SELENOP [99]

Additionally, a review of 12 studies found that supplementing with berberine led to significant reductions in body weight, body mass index, and belly fat