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Under conditions of hypoxia, nutrient deprivation, or impaired mitochondrial function, cancer cells modulate NADPH and GSH levels through key metabolic pathways such as the pentose phosphate pathway (PPP), FAO, and glutamine metabolism, thereby establishing a metabolicredox feedback loop [39,40,41]

[58] Clarithromycin and azithromycin, though less studied for this indication, share the same mechanism of action and (limited) utility

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Hepatic steatosis is associated with the alteration of nuclear receptors, membrane transport proteins and cellular enzymes [14,15]