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SIRT1 activation promotes numerous anti-aging effects including enhanced mitochondrial biogenesis, improved stress resistance, reduced inflammation, and activation of cellular quality control mechanisms that remove damaged proteins and organelles

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598 Nedd4 family interacting protein 1 (Ndfip1), an adaptor protein for the Nedd4 E3 ubiquitin ligase, shows reduced expression in the substantia nigra of PD mouse models