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the mitochondrial glutamate oxaloacetate transaminase ( Got2 ) gene which synthesizes glutamate from aspartate and -ketoglutarate [59], and Oxoglutarate dehydrogenase (Ogdh) , a mitochondrial complex member associated with glutamate degradation [60], which regulates neurotransmitter glutamate levels and is implicated in the stress response [61]

With more and more people using GLP-1 receptor agonists for diabetes and weight management, healthcare providers are becoming more aware of ways both positive and negative these medications impact the body

Experimental Gerontology (2020) 12

And bonus: Healthier habits like prioritizing nutritious foods and getting enough exercise can also help manage side effects alongside maximizing weight loss

Alterations in the expression of these genes may disrupt neural plasticity and emotional regulation, thereby contributing to the development of depression