Considering the prolonged half-life of most GLP-1 agonists currently prescribed, it is unfeasible to withhold these agents for weeks prior to surgery to achieve normalisation of gastric function with unknown impact on aspiration rates, appreciating the detrimental effects of poorer glycaemic control on withholding these agents and associated higher risk of peri/postoperative complications (major cardiovascular events, poor wound healing, increased wound infection etc.)
Data gaps : Many peptides used in wellness clinics have stronger animal or smallscale human data than large, longterm randomized trials in healthy adults
For example, Lactiplantibacillus plantarum reduces the DNA-binding capacity of NF-B, thereby limiting the transcription of pro-inflammatory genes (258), whereas Lactobacillus brevis inhibits the phosphorylation of upstream kinases such as IRAK1 and AKT (259)
Sodium R-Alpha-Lipoate (Na-RALA) A stabilized sodium salt form of R-alpha-lipoic acid, known as sodium R-alpha-lipoate (Na-RALA), has been developed to address stability issues with pure R-lipoic acid (which can polymerize and degrade)
In dogs, hair normally passes easily through the digestive system, but this hairball was wrapped around a brillo pad that was too big to move through
