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While epidemiological data are limited, cross sectional studies from the UK and US suggest a prevalence of 3% in people aged 20-39, increasing with age up to about 20% in people aged 85 and over.12 Complications of vitamin B 12 deficiency include visual changes, paraesthesia, and ataxia

Results from two systematic reviews with meta-analyses of clinical trials and observational studies were conflicting regarding the reduction of depressive symptoms

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The role of gravity cannot be overlooked either

Both agents affect vascular function and hemostasis through independent mechanisms with potential for additive bleeding effects