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For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50

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Candidate polymorphisms in this context include cSHMT -C1420T, a common gene variant in cSHMT which results in an amino acid substitution that prevents the multienzyme complex from undergoing localization to the nucleus

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